http://hdl.handle.net/20.500.12283/2 Fri, 03 Apr 2026 19:59:20 GMT 2026-04-03T19:59:20Z http://hdl.handle.net/20.500.12283/3043 The Uganda Higher Education Review. National Council for Higher Education The Uganda Higher Education Review: Journal of the National Council for Higher Education (NCHE) provides a visible outlet for definitive articles that discuss the theory, practice and policies relating to the role, development, management and improvement of higher education from a national, regional and international viewpoint. The journal provides a platform for scholars, researchers and higher education institutions to make a contribution to scholarly debate through the publication of quality peer-reviewed articles. The journal publication is done twice a year, that is in May and September. The journal is committed to the publication of both experienced and early career researchers so its editorial policy pays overriding attention to helping contributors to reach the level of quality that is deemed fit for the publication through ensuring relevant, fair and penetrating reviews as well as timely relay of feedback to contributors. The objective of the journal is to publish original research on higher education. The primary aim of this journal is the dissemination of important research work that will promote a sustainable, accessible and quality higher education that is relevant for social transformation. Aims and Scope The Uganda Higher Education Review is a broad-based journal that covers all aspects of higher education. Papers containing new ideas, creative approaches and/or innovative applications are welcome. Papers that discuss the theory, practice and policies relating to the role, development, management and improvement of higher education from national, regional and international viewpoints are sought. NB: The journal is open access. This journal is a product of the call for papers and research areas of focus in this volume10, issue 1, 2022, and include the following: 1. General enrolment ratio (GER). 2. Sustainable development and management of academic staff. 3. Higher education funding. 4. Innovations to increase STEM enrolment as well as supporting the teaching and learning of STEM. 5. Building research and innovation capacity Journal articles Sat, 01 Jan 2022 00:00:00 GMT http://hdl.handle.net/20.500.12283/3043 2022-01-01T00:00:00Z http://hdl.handle.net/20.500.12283/2688 Community contribution to the control of Ebola outbreaks in Uganda, 2000-2022. Okware, Samuel Community contribution to the control of Ebola outbreaks in Uganda, 2000-2022 Research article Sat, 01 Oct 2022 00:00:00 GMT http://hdl.handle.net/20.500.12283/2688 2022-10-01T00:00:00Z http://hdl.handle.net/20.500.12283/2687 Strategies for the development of small molecule inhibitors of ebola viral infection. Pleško, Sebastian; Podlipnik, Črtomir The recent outbreak of Ebola viral disease (EVD) in West Africa reminded us that an effective anti-viral treatment still does not exist, despite the significant progress that has recently been made in understanding biology and pathology of this lethal disease. Currently, there are no approved vaccine and/or prophylactic medication for the treatment of EVD in the market. However, the serious pandemic potential of EVD mobilized research teams in the academy and the pharmaceutical industry in the effort to find an Ebola cure as fast as possible. In this chapter, we are giving the condensed review of different approaches and strategies in search of a drug against Ebola. We have been focusing on the review of the targets that could be used for in silico, in vitro, and/or in vivo drug design of compounds that interact with the targets in different phases of the Ebola virus life cycle. Keywords: small molecule inhibitors, Ebola virus, drug design, protein targets, structure and action Book chapter Fri, 01 Jan 2016 00:00:00 GMT http://hdl.handle.net/20.500.12283/2687 2016-01-01T00:00:00Z http://hdl.handle.net/20.500.12283/2686 Ebola virus’s glycoproteins and entry mechanism. Khataby, Khadija; Kasmi, Yassine; Hammou, Rahma Ait; Laasri, Fatima Ezzahra; Boughribil, Said; Ennaji, My Mustapha Ebola virus glycoprotein (GP) is the only protein that is expressed on the surface of the virus. The GP proteins play critical roles in the entry of virus into cell and in the evasion of the immune system. The GP gene transcript to membrane GP is constituted of two subunits GP1 and GP2,and the secretory GP (sGP). The main function of GP1/2 is to attach virus to target cell’s membrane, whereas sGP has multiple functions on Ebola pathogen‐ esis, such as inactivate neutrophils through CD16b causing lymphocyte apoptosis and vascular dysregulation. There are many studies that focused on better understanding the GP mechanism and aim at developing new antibodies and drugs such as VSV-EBOV, cAd3-EBO Z, rVSVN4CT1 VesiculoVax, ‘C-peptide’ based on the GP2 C-heptad repeat region (CHR) targeted to endosomes (Tat-Ebo) and MBX2270. In this chapter, we discuss the Ebola viral glycoproteins, genomic organization, synthesis, and their roles and functions. On the other hand, we treat the mechanisms of pathogenicity associated with Ebola GPs. Keywords: EBOLA, virus, glycoprotein (GP), entry, mechanism, pathogenesis, structure Book chapter Fri, 01 Jan 2016 00:00:00 GMT http://hdl.handle.net/20.500.12283/2686 2016-01-01T00:00:00Z