Abstract:
Ebola epidemic is a fatal disease due to Ebola virus belonging to Filoviridae; currently the
viral evolution caused more than 50% of death worldwide. Among the eight proteins of
ZEBOV, there are four structural proteins VP35, VP40, VP24, and NP, which have
important functions in the intercellular pathogenic mechanisms. The multi‐functionali‐
ty of Ebola's viral proteins allows the virus to reduce its protein number to ensure its
proper functioning and keeping the compact structure of the virus. Therefore, the aim of
this chapter is to study the mechanism of replication and the roles of VP30, VP35, NP, and
L in this process. We provide as well to highlight the influence of the virus on the immune
system and on the VP24.
Keywords: Ebola, VP35, VP40, VP24, pathogenic, replication, mechanisms, immune
system
