Abstract:
The recent outbreak of Ebola viral disease (EVD) in West Africa reminded us that an
effective anti-viral treatment still does not exist, despite the significant progress that has
recently been made in understanding biology and pathology of this lethal disease.
Currently, there are no approved vaccine and/or prophylactic medication for the
treatment of EVD in the market. However, the serious pandemic potential of EVD
mobilized research teams in the academy and the pharmaceutical industry in the effort
to find an Ebola cure as fast as possible. In this chapter, we are giving the condensed
review of different approaches and strategies in search of a drug against Ebola. We have
been focusing on the review of the targets that could be used for in silico, in vitro, and/or
in vivo drug design of compounds that interact with the targets in different phases of
the Ebola virus life cycle.
Keywords: small molecule inhibitors, Ebola virus, drug design, protein targets, structure and action
