Faculty of Health Scienceshttp://hdl.handle.net/20.500.12283/682024-03-29T02:33:19Z2024-03-29T02:33:19ZCommunity contribution to the control of Ebola outbreaks in Uganda, 2000-2022.Okware, Samuelhttp://hdl.handle.net/20.500.12283/26882022-11-30T16:18:09Z2022-10-01T00:00:00ZCommunity contribution to the control of Ebola outbreaks in Uganda, 2000-2022.
Okware, Samuel
Community contribution to the control of Ebola outbreaks in
Uganda, 2000-2022
Research article
2022-10-01T00:00:00ZStrategies for the development of small molecule inhibitors of ebola viral infection.Pleško, SebastianPodlipnik, Črtomirhttp://hdl.handle.net/20.500.12283/26872022-11-29T16:16:46Z2016-01-01T00:00:00ZStrategies for the development of small molecule inhibitors of ebola viral infection.
Pleško, Sebastian; Podlipnik, Črtomir
The recent outbreak of Ebola viral disease (EVD) in West Africa reminded us that an
effective anti-viral treatment still does not exist, despite the significant progress that has
recently been made in understanding biology and pathology of this lethal disease.
Currently, there are no approved vaccine and/or prophylactic medication for the
treatment of EVD in the market. However, the serious pandemic potential of EVD
mobilized research teams in the academy and the pharmaceutical industry in the effort
to find an Ebola cure as fast as possible. In this chapter, we are giving the condensed
review of different approaches and strategies in search of a drug against Ebola. We have
been focusing on the review of the targets that could be used for in silico, in vitro, and/or
in vivo drug design of compounds that interact with the targets in different phases of
the Ebola virus life cycle.
Keywords: small molecule inhibitors, Ebola virus, drug design, protein targets, structure and action
Book chapter
2016-01-01T00:00:00ZEbola virus’s glycoproteins and entry mechanism.Khataby, KhadijaKasmi, YassineHammou, Rahma AitLaasri, Fatima EzzahraBoughribil, SaidEnnaji, My Mustaphahttp://hdl.handle.net/20.500.12283/26862022-11-29T16:08:52Z2016-01-01T00:00:00ZEbola virus’s glycoproteins and entry mechanism.
Khataby, Khadija; Kasmi, Yassine; Hammou, Rahma Ait; Laasri, Fatima Ezzahra; Boughribil, Said; Ennaji, My Mustapha
Ebola virus glycoprotein (GP) is the only protein that is expressed on the surface of the
virus. The GP proteins play critical roles in the entry of virus into cell and in the evasion
of the immune system. The GP gene transcript to membrane GP is constituted of two
subunits GP1 and GP2,and the secretory GP (sGP). The main function of GP1/2 is to attach
virus to target cell’s membrane, whereas sGP has multiple functions on Ebola pathogen‐
esis, such as inactivate neutrophils through CD16b causing lymphocyte apoptosis and
vascular dysregulation. There are many studies that focused on better understanding the
GP mechanism and aim at developing new antibodies and drugs such as VSV-EBOV,
cAd3-EBO Z, rVSVN4CT1 VesiculoVax, ‘C-peptide’ based on the GP2 C-heptad repeat
region (CHR) targeted to endosomes (Tat-Ebo) and MBX2270. In this chapter, we discuss
the Ebola viral glycoproteins, genomic organization, synthesis, and their roles and
functions. On the other hand, we treat the mechanisms of pathogenicity associated with
Ebola GPs.
Keywords: EBOLA, virus, glycoprotein (GP), entry, mechanism, pathogenesis, structure
Book chapter
2016-01-01T00:00:00ZRoles of VP35, VP40 and VP24 proteins of ebola virus in pathogenic and replication mechanisms.Hammou, Rahma AitKasmi, YassineKhataby, KhadijaLaasri, Fatima EzzahraBoughribil, SaidEnnaji, My Mustaphahttp://hdl.handle.net/20.500.12283/26852022-11-29T15:59:34Z2016-01-01T00:00:00ZRoles of VP35, VP40 and VP24 proteins of ebola virus in pathogenic and replication mechanisms.
Hammou, Rahma Ait; Kasmi, Yassine; Khataby, Khadija; Laasri, Fatima Ezzahra; Boughribil, Said; Ennaji, My Mustapha
Ebola epidemic is a fatal disease due to Ebola virus belonging to Filoviridae; currently the
viral evolution caused more than 50% of death worldwide. Among the eight proteins of
ZEBOV, there are four structural proteins VP35, VP40, VP24, and NP, which have
important functions in the intercellular pathogenic mechanisms. The multi‐functionali‐
ty of Ebola's viral proteins allows the virus to reduce its protein number to ensure its
proper functioning and keeping the compact structure of the virus. Therefore, the aim of
this chapter is to study the mechanism of replication and the roles of VP30, VP35, NP, and
L in this process. We provide as well to highlight the influence of the virus on the immune
system and on the VP24.
Keywords: Ebola, VP35, VP40, VP24, pathogenic, replication, mechanisms, immune
system
Book chapter
2016-01-01T00:00:00Z