Browsing Research Papers by Author "Gibb, Diana M."

Browsing Research Papers by Author "Gibb, Diana M."

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  • Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness 
    Kiguli, Sarah; Maitland, Kathryn; George, Elizabeth C.; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M.; Crawley, Jane (BMC, 2015)
    Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group. Methods: ...
  • Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial 
    Maitland, Kathryn; Olupot-Olupot, Peter; Kiguli, Sarah; Chagaluka, George; Alaroker, Florence; Opoka, Robert O; Mpoya, Ayub; Walsh, Kevin; Engoru, Charles; Nteziyaremye, Julius; Mallewa, Machpherson; Kennedy, Neil; Nakuya, Margaret; Namayanja, Cate; Kayaga, Julianne; Nabawanuka, Eva; Sennyondo, Tonny; Aromut, Denis; Kumwenda, Felistas; Bates, Imelda; von Hensbroek, Michael Boele; Evans, Jennifer A; Uyoga, Sophie; Williams, Thomas N; Frost, Gary; George, Elizabeth C.; Gibb, Diana M.; Walker, A Sarah (Elsevier, 2019)
    Background Severe anaemia is a leading cause of paediatric admission to hospital in Africa; post-discharge outcomes remain poor, with high 6-month mortality (8%) and re-admission (17%). We aimed to investigate ...
  • Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration 
    Houston, Kirsty A.; Gibb, Jack G.; Mpoya, Ayub; Obonyo, Nchafatso; Olupot-Olupot, Peter; Nakuya, Margeret; Evans, Jennifer; George, Elizabeth C.; Gibb, Diana M.; Maitland, Kathryn (Wellcome Trust, 2017)
    Background: The World Health Organization (WHO) rehydration management guidelines (Plan C) for children with acute gastroenteritis (AGE) and severe dehydration are widely practiced in resource-poor settings, yet have ...
  • High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in Eastern Uganda 
    Olupot-Olupot, Peter; Engoru, Charles; Uyoga, Sophie; Muhindo, Rita; Macharia, Alex; Kiguli, Sarah; Opoka, Robert O.; Akech, Samuel; Ndila, Carolyne; Nyeko, Richard; Mtove, George; Nteziyaremye, Julius; Chebet, Martin; George, Elizabeth C.; Babiker, Abdel G.; Gibb, Diana M.; Williams, Thomas N.; Maitland, Kathryn (Oxford University Press, 2017)
    Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods. We describe the prevalence ...
  • Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa 
    Aramburo, A.; Todd, Jim; George, Elizabeth C.; Kiguli, Sarah; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Gibb, Diana M.; Babiker, Abdel G.; Maitland, Kathryn (BMC, 2018)
    Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ...
  • Mortality after fluid bolus in African children with severe infection 
    Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O.; CEngoru, Charles; Olupot-Olupot, Peter; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Lang, Trudie; Brent, Bernadette; Evans, A. Evans; Tibenderana, James K.; Crawley, Jane; Russell, Elizabeth C.; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M. (Massachusetts Medical Society, 2011)
    Background The role of fluid resuscitation in the treatment of children with shock and lifethreatening infections who live in resource-limited settings is not established. Methods We randomly assigned children with ...
  • Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia 
    Olupot-Olupot, Peter; Engoru, Charles; Thompson, Jennifer; Nteziyaremye, Julius; Chebet, Martin; Ssenyondo, Tonny; Dambisya, Cornelius M.; Okuuny, Vicent; Wokulira, Ronald; Amorut, Denis; Ongodia, Paul; Mpoya, Ayub; Williams, Thomas N.; Uyoga, Sophie; Macharia, Alex; Gibb, Diana M.; Walker, A. Sarah; Maitland, Kathryn (BMC, 2018)
    Background: Severe anemia (SA, hemoglobin <6 g/dl) is a leading cause of pediatric hospital admission in Africa, with significant in-hospital mortality. The underlying etiology is often infectious, but specific pathogens ...
  • Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score 
    George, Elizabeth C.; Walker, Sarah; Kiguli, Sarah; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Berkley, James A.; Mpoya, Ayub; Levin, Michael; Crawley, Jane; Gibb, Diana M.; Maitland, Kathryn; Babiker, Abdel G. (BMC, 2015)
    Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ...
  • Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial 
    Mpoya, Ayub; Olupot-Olupot, Peter; Kiguli, Sarah; Opoka, Robert O.; Engoru, Charles; Macpherson, Mallewa; Chimalizeni, Yami; Kennedy, Neil; Kyeyune, Dorothy; Wabwire, Benjamin; M’baya, Bridon; Bates, Imelda; Urban, Britta C,; van Hensbroek, Michael Boele; Heyderman, Robert; Thomason, Margaret J.; Uyoga, Sophie; Williams, Thomas N.; Gibb, Diana M.; George, Elizabeth C.; Walker, Sarah; Maitland, Kathryn (BMC, 2015)
    Background: In sub-Saharan Africa, where infectious diseases and nutritional deficiencies are common, severe anaemia is a common cause of paediatric hospital admission, yet the evidence to support current treatment rec ...

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