A Descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials among healthcare workers in Uganda

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dc.contributor.author Kasozi, Keneth Iceland
dc.contributor.author Laudisoit, Anne
dc.contributor.author Osuwat, Lawrence Obado
dc.contributor.author Batiha, Gaber El-Saber
dc.contributor.author Omairi, Naif E. Al
dc.contributor.author Aigbogun, Eric
dc.contributor.author Ninsiima, Herbert Izo
dc.contributor.author Usman, Ibe Michael
dc.contributor.author DeTora, Lisa M.
dc.contributor.author MacLeod, Ewan Thomas
dc.date.accessioned 2021-05-06T09:12:32Z
dc.date.available 2021-05-06T09:12:32Z
dc.date.issued 2021
dc.identifier.citation Kasozi, K.I., . . . et al. (2021). A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda. Vaccines 2021, 9, 253. https://doi.org/10.3390/vaccines9030253 en_US
dc.identifier.uri http://hdl.handle.net/20.500.12283/741
dc.description Article en_US
dc.description.abstract Background—misinformation and mistrust often undermines community vaccine uptake, yet information in rural communities, especially of developing countries, is scarce. This study aimed to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical trials among healthcare workers and staff in Uganda. Methods—a rapid exploratory survey was conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the country using an online questionnaire. Twenty-seven questions assessed knowledge, confidence, and trust scores on COVID-19 vaccine clinical trials from participants in 46 districts in Uganda. Results—we found low levels of knowledge (i.e., confusing COVID-19 with Ebola) with males being more informed than females (OR = 1.5, 95% CI: 0.7–3.0), and mistrust associated with policy decisions to promote herbal treatments in Uganda and the rushed international clinical trials, highlighting challenges for the upcoming Oxford–AstraZeneca vaccinations. Knowledge, confidence and trust scores were higher among the least educated (certificate vs. bachelor degree holders). We also found a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as the Oxford–AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI: 10.7–19.3) currently being promoted by the Ugandan government raises major policy concerns. High fear and mistrust for COVID-19 vaccine clinical trials was more common among wealthier participants and more affluent regions of the country. Conclusion—our study found that knowledge, confidence, and trust in COVID-19 vaccines was low among healthcare workers in Uganda, especially those with higher wealth and educational status. There is a need to increase transparency and inclusive participation to address these issues before new trials of COVID-19 vaccines are initiated. Keywords: COVID-19 clinical trials in resource poor countries; COVID-19; clinical trials in Africa; COVID-19 and medical workers; vaccines; COVAX en_US
dc.description.sponsorship University of Edinburgh, Soroti University, Mbarara University of Science and Technology, Busitema University en_US
dc.language.iso en en_US
dc.publisher Busitema University ; MDPI en_US
dc.subject COVID-19 clinical trials in resource poor countries en_US
dc.subject COVID-19 en_US
dc.subject Clinical trials in Africa en_US
dc.subject COVID-19 and medical workers en_US
dc.subject Vaccines ; en_US
dc.subject COVAX en_US
dc.title A Descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials among healthcare workers in Uganda en_US
dc.type Article en_US

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