Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)

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dc.contributor.author Gavamukulya, Yahaya
dc.contributor.author Abou-Elella, Faten
dc.contributor.author Wamunyokoli, Fred
dc.contributor.author AEl-Shemy, Hany
dc.date.accessioned 2018-09-17T10:12:49Z
dc.date.available 2018-09-17T10:12:49Z
dc.date.issued 2014
dc.identifier.issn 2352-4146
dc.identifier.uri http://hdl.handle.net/20.500.12283/125
dc.description Article en_US
dc.description.abstract Objective: To determine the phytochemical composition, antioxidant and anticancer ethanolic and water leaves extracts of Annona muricata (A. muricata) from the Eastern aUcgtiavnitdiae.s of Methods: Phytochemical screening was conducted using standard qualitative methods danifdfe rae nCth pi-hystqoucahreem gicoaoldsn. eTshse oafn ftiito xtiedsat nwt aasc tuivsietdy wtoa sa sdseitgenrm thinee dre ulastiinvge tahbe u2n, d2a-ndciep hoefn tyhl-e 2d-etpeircmryinlheydd ursaiznygl tahnrede rdeidffuecreinngt cpeollw leinr ems. ethods whereas the in vitro anticancer activity was Results: Phytochemical screening of the extracts revealed that they were rich in secondary clalacstosn mese,t aabnothlirtaeq cuoinmopnoeusn, dtasn snuicnhs, acsa radlkiaacl ogidlysc, ossaidpeosn,i npsh, etneorplse nanoidd sp,h fylatovsotneoroidlss., Tcootuaml pahriennso alincds in the water extract were (683.69依0.09) μg/mL gallic acid equivalents (GAE) while it was (372.92 e依x0t.r1a5c) tμ agn/md L47 G0.A51E μ ign/ mthLe GeAthEa nino ltihce eextthraancot.l iTch eex trreadcut.c Iinn gv iptroow aenr tiwoaxsid 2a1n6t. 4a1c tμivgi/tmy LIC in the water mg/mL and 0.9077 mg/mL for ethanolic and water leaves extracts of A. muricata respe5c0 twivaesl y2.. 0T4h5e6 ethanolic leaves extract was found to be selectively cytotoxic in vitro to tumor cell lines (EACC, Mit DhaAd a nnod cSyKtoBtRox3i)c w eiftfhe cICt o50n v nalouremsa ol fs p33le5.e8n5 cμegl/lms. L, 248.77 μg/mL, 202.33 μg/mL respectively, while The data also showed that water leaves extract of A. muricata had no anticancer effect at all tested concentrations. Conclusions: The results showed that A. muricata was a promising new antioxidant and anticancer agent en_US
dc.description.sponsorship Pan African University, African Union Commission, Government of Kenya, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Cairo University en_US
dc.language.iso en en_US
dc.publisher Medknow Publications en_US
dc.subject Annona muricata en_US
dc.subject Phytochemical screening en_US
dc.subject Antioxidant en_US
dc.subject Anticancer en_US
dc.title Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola) en_US
dc.type Article en_US


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