Browsing Faculty of Health Sciences by Issue Date

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Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides

Mpagi, Joseph L.; Rickert, Rainer; Steinhart, Hans; Brattig, Norbert W. (American Society of Tropical Medicine and Hygiene, 2000)

The mechanism by which the minority of patients with onchocerciasis exhibiting the hyperreactive (sowda) form of the disease may be able to kill the microfilariae of Onchocerca volvulus is still poorly understood. In ...
The secretory Onchocerca voluulus protein OvS1:Ov20 exhibits the capacity to compete with serum albumin for the host’s long-chain fatty acids

Mpagi, Joseph L.; Erttmann, Klaus D.; Brattig, Norbert W. (Elsevier, 2000)

The mechanism by which filarial parasites derive fatty acids bound to the host’s carrier protein is poorly understood. The capacity of a secretory protein of Onchocerca 6ol6ulus (OvS1:Ov20) to compete with serum albumin for ...
Toll-Like Receptor 2-Deficient Mice Succumb to Mycobacterium tuberculosis Infection

Drennan, Michael B.; Nicolle, Delphine; Quesniaux, Valerie J. F.; Jacobs, Muazzam; Allie, Nasiema; Mpagi, Joseph L.; Fremond, Cecile; Wagner, Hermann; Kirschning, Carsten; Ryffe, Bernhard (Elsevier, 2004)

Recognition of Mycobacterium tuberculosis by the innate immune system is essential in the development of an adaptive immune response. Mycobacterial cell wall components activate macrophages through Toll-like receptor ...
Special section: A multinational injury surveillance system pilot project in Africa

Zavala, Diego E.; Bokongo, Simon; Ime, A. John; Senoga, Ismail Mpanga; Mtonga, Robert E.; Aminu, Zakari Mohammed; Odhiambo, Walter; Olupot-Olupot, Peter (Palgrave Macmillan, 2007)

This paper describes the development of a pilot project to test the implementation of an epidemiological surveillance system for intentional (violent) and non-intentional injuries, at emergency departments in selected ...
Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda

Kiboneka, Andrew; Wangisi, Jonathan; Nabiryo, Christine; Tembe, Juliet; Kusemererwa, Sylvia; Joffres, Michel; Olupot-Olupot, Peter; Anema, Aranka; Cooper, Curtis L.; Montaner, Julio S.; Mills, Edward J. (Lippincott, Williams & Wilkins, 2008)

Objective: We aimed to evaluate clinical and immunological outcomes of paediatric patients receiving combination antiretroviral therapy (cART) enrolled in The AIDS Support Organization (TASO) Uganda national HIV/AIDS ...
Existing capacity to manage pharmaceuticals and related commodities in East Africa: an assessment with specific reference to antiretroviral therapy

Waako, Paul J.; Odoi-adome, Richard; Obua, Celestino; Owino, Erisa; Tumwikirize, Winnie; Ogwal-okeng, Jasper; Anokbonggo, Willy W.; Matowe, Lloyd; Aupont, Onesky (BMC, 2009)

Background: East African countries have in the recent past experienced a tremendous increase in the volume of antiretroviral drugs. Capacity to manage these medicines in the region remains limited. Makerere University, ...
Mortality after fluid bolus in African children with severe infection

Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O.; CEngoru, Charles; Olupot-Olupot, Peter; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Lang, Trudie; Brent, Bernadette; Evans, A. Evans; Tibenderana, James K.; Crawley, Jane; Russell, Elizabeth C.; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M. (Massachusetts Medical Society, 2011)

Background The role of fluid resuscitation in the treatment of children with shock and lifethreatening infections who live in resource-limited settings is not established. Methods We randomly assigned children with ...
Prevalence and factors associated with traditional herbal medicine use among patients on highly active antiretroviral therapy in Uganda

Namuddu, Betty; Kalyango, Joan N; Karamagi, Charles; Mudiope, Peter; Sumba, Samwel; Kalende, Henry; Wobudeya, Eric; Kigozi, Brian K; Waako, Paul J. (BMC, 2011)

Background: In Africa, herbal medicines are often used as primary treatment for Human immunodeficiency virus (HIV) related problems. Concurrent use of traditional herbal medicines (THM) with antiretroviral drugs (ARVs) ...
Identification of coding sequences from a freshly prepared Trypanosoma brucei brucei expression library by polymerase chain reaction

Okalang, Uthman; Nanteza, Ann; Matovu, Enock; Lubega, George W. (e-Century Publishing, 2013)

Abstract: Animal African trypanosomiasis (AAT) also known as Nagana is a devastating disease among domestic animals in large parts of Sub-Saharan Africa causing loses in milk and meat production as well as traction power. ...
Endotoxaemia is common in children with Plasmodium falciparum malaria

Olupot-Olupot, Peter; Urban, Britta C,; Jemutai, Julie; Nteziyaremye, Julius; Fanjo, Harry M.; Karanja, Henry; Karisa, Japhet; Ongodia, Paul; Bwonyo, Patrick; Gitau, Evelyn N.; Talbert, Alison; Akech, Samuel; Maitland, Kathryn (BMC, 2013)

Background: Children presenting to hospital with recent or current Plasmodium falciparum malaria are at increased the risk of invasive bacterial disease, largely enteric gram-negative organisms (ENGO), which is associated ...
‘The words will pass with the blowing wind’: staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two african hospitals

Molyneux, Sassy; Njue, Maureen; Boga, Mwanamvua; Akello, Lilian; Olupot-Olupot, Peter; Engoru, Charles; Kiguli, Sarah; Maitland, Kathryn (Public Library of Science, 2013)

Objective: To document and explore the views and experiences of key stakeholders regarding the consent procedures of an emergency research clinical trial examining immediate fluid resuscitation strategies, and to discuss ...
Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)

Gavamukulya, Yahaya; Abou-Elella, Faten; Wamunyokoli, Fred; AEl-Shemy, Hany (Medknow Publications, 2014)

Objective: To determine the phytochemical composition, antioxidant and anticancer ethanolic and water leaves extracts of Annona muricata (A. muricata) from the Eastern aUcgtiavnitdiae.s of Methods: Phytochemical screening ...
Predictors of unknown HIV serostatus at the time of labor and delivery in Kampala, Uganda

Ononge, Sam; Karamagi, Charles; Nakabiito, Clemensia; Wandabwa, Julius; Mirembe, Florence; Rukundo, Godfrey Z.; Jennings, Larissa (Wiley, 2014)

Objective—To determine factors associated with an unknown HIV serostatus among pregnant women admitted in labor to Mulago Hospital, Kampala, Uganda. Methods—In total, 665 pregnant women admitted to Mulago Hospital were ...
Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants

Kiguba, Ronald; Karamagi, Charles; Waako, Paul J.; Ndagije, Helen B.; Bird, Sheila M. (BMJ Publishing Group, 2014)

Objective: To assess extent and determinants of pastmonth recognition of suspected adverse drug reactions (ADR) and past-year ADR reporting among healthcare professionals (HCPs) in Uganda. Setting: Geographically diverse ...
Factors predicting home storage of medicines in Northern Uganda

Ocan, Moses; Bbosa, Godfrey S; Waako, Paul J.; Ogwal-Okeng, Jasper; Obua, Celestino (BMC, 2014)

Background: Medicines are kept in households Worldwide for first aid, treatment of chronic or acute disease conditions. This promotes inappropriate use of medicines and hence the associated risks. The study explored ...
GC-MS analysis of bioactive phytochemicals present in ethanolic extracts of leaves of Annona muricata: A further evidence for its medicinal diversity

Gavamukulya, Yahaya; Abou-Elella, Faten; Wamunyokoli, Fred; El-Shemy, Hany A. (Emanuscript Services, 2015)

Background: Folk medicine has taken an important place especially in de¬veloping countries where limited health services are available. However, the absence of scientific evaluation of medicinal plants may cause serious ...
Ebola in children : Epidemiology, clinical features,diagnosis and outcomes

Olupot-Olupot, Peter (Lippincott, Williams & Wilkins, 2015)

Abstract: Ebola virus disease is caused by a highly contagious and pathogenic threadlike RNA virus of the Filoviridae family. The index human case is usually a zoonosis that launches human-to-human transmission interface ...
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score

George, Elizabeth C.; Walker, Sarah; Kiguli, Sarah; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Berkley, James A.; Mpoya, Ayub; Levin, Michael; Crawley, Jane; Gibb, Diana M.; Maitland, Kathryn; Babiker, Abdel G. (BMC, 2015)

Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ...
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness

Kiguli, Sarah; Maitland, Kathryn; George, Elizabeth C.; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M.; Crawley, Jane (BMC, 2015)

Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group. Methods: ...
Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

Mpoya, Ayub; Olupot-Olupot, Peter; Kiguli, Sarah; Opoka, Robert O.; Engoru, Charles; Macpherson, Mallewa; Chimalizeni, Yami; Kennedy, Neil; Kyeyune, Dorothy; Wabwire, Benjamin; M’baya, Bridon; Bates, Imelda; Urban, Britta C,; van Hensbroek, Michael Boele; Heyderman, Robert; Thomason, Margaret J.; Uyoga, Sophie; Williams, Thomas N.; Gibb, Diana M.; George, Elizabeth C.; Walker, Sarah; Maitland, Kathryn (BMC, 2015)

Background: In sub-Saharan Africa, where infectious diseases and nutritional deficiencies are common, severe anaemia is a common cause of paediatric hospital admission, yet the evidence to support current treatment rec ...

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