Textile assemblies for transdermal delivery of plumeria obtusa extract for medical application.

Abstract

As science and technology has developed the manner by which drugs can be delivered has grown. Medicines may be taken orally, applied as topical pastes, creams or patches or administered by direct injection to the body cells. This research explores an alternative method for the delivery of therapeutic compounds to the body. The basis of the study involves the application of plumeria obtusa extract used to treat fungal infection and respectively through transdermal topical application, using a textile substrate as the carrier. Different performance, durability and drug delivery tests (such as wash fastness, rub fastness and invitro, percutaneous tests) were carried out. The P.O extract was found to adhere to woven cotton fabric. The fabricated medical textile had lower tub fastness value showing a higher presence of P.O extract on the adjacent cotton fabric and the high wash fastness values indicate the negligible transfer of the P.O extract on to the adjacent simulated skin. Using simulated skin, the loss of the fabric weights in invitro, percutaneous test showed significant transfer of P. O extract from fabric through the skin. Keywords; Drug delivery, transdermal, plumeria obtusa, invitro percutaneous, Textiles, cotton.