Browsing Faculty of Health Sciences by Author "Engoru, Charles"

Browsing Faculty of Health Sciences by Author "Engoru, Charles"

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  • Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness 
    Kiguli, Sarah; Maitland, Kathryn; George, Elizabeth C.; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M.; Crawley, Jane (BMC, 2015)
    Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group. Methods: ...
  • Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia 
    Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O.; Olupot-Olupot, Peter; Engoru, Charles; Njuguna, Patricia; Bandika, Victor; Mpoya, Ayub; Bush, Andrew; Williams, Thomas N.; Grieve, Richard; Sadique, Zia; Fraser, John; Harrison, David; Rowan, Kathy (Wellcome Trust, 2018)
    Background: In Africa, the clinical syndrome of pneumonia remains the leading cause of morbidity and mortality in children in the post-neonatal period. This represents a significant burden on in-patient services. The ...
  • Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial 
    Maitland, Kathryn; Olupot-Olupot, Peter; Kiguli, Sarah; Chagaluka, George; Alaroker, Florence; Opoka, Robert O; Mpoya, Ayub; Walsh, Kevin; Engoru, Charles; Nteziyaremye, Julius; Mallewa, Machpherson; Kennedy, Neil; Nakuya, Margaret; Namayanja, Cate; Kayaga, Julianne; Nabawanuka, Eva; Sennyondo, Tonny; Aromut, Denis; Kumwenda, Felistas; Bates, Imelda; von Hensbroek, Michael Boele; Evans, Jennifer A; Uyoga, Sophie; Williams, Thomas N; Frost, Gary; George, Elizabeth C.; Gibb, Diana M.; Walker, A Sarah (Elsevier, 2019)
    Background Severe anaemia is a leading cause of paediatric admission to hospital in Africa; post-discharge outcomes remain poor, with high 6-month mortality (8%) and re-admission (17%). We aimed to investigate ...
  • Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalized children in Eastern Uganda 
    Olupot-Olupot, Peter; Prevatt, Natalie; Engoru, Charles; Nteziyaremye, Nteziyaremye; Amorut, Denis; Chebet, Martin; Senyondo, Tonny; Ongodia, Paul; Ndila, Carolyne M.; Williams, Thomas N.; Maitland, Kathryn (F1000Research, 2018)
    Background: Severe anaemia in children requiring hospital admission is a major public health problem in malaria-endemic Africa. Affordable methods for the assessment of haemoglobin have not been validated against gold ...
  • High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in Eastern Uganda 
    Olupot-Olupot, Peter; Engoru, Charles; Uyoga, Sophie; Muhindo, Rita; Macharia, Alex; Kiguli, Sarah; Opoka, Robert O.; Akech, Samuel; Ndila, Carolyne; Nyeko, Richard; Mtove, George; Nteziyaremye, Julius; Chebet, Martin; George, Elizabeth C.; Babiker, Abdel G.; Gibb, Diana M.; Williams, Thomas N.; Maitland, Kathryn (Oxford University Press, 2017)
    Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods. We describe the prevalence ...
  • Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa 
    Aramburo, A.; Todd, Jim; George, Elizabeth C.; Kiguli, Sarah; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Gibb, Diana M.; Babiker, Abdel G.; Maitland, Kathryn (BMC, 2018)
    Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ...
  • Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia 
    Olupot-Olupot, Peter; Engoru, Charles; Thompson, Jennifer; Nteziyaremye, Julius; Chebet, Martin; Ssenyondo, Tonny; Dambisya, Cornelius M.; Okuuny, Vicent; Wokulira, Ronald; Amorut, Denis; Ongodia, Paul; Mpoya, Ayub; Williams, Thomas N.; Uyoga, Sophie; Macharia, Alex; Gibb, Diana M.; Walker, A. Sarah; Maitland, Kathryn (BMC, 2018)
    Background: Severe anemia (SA, hemoglobin <6 g/dl) is a leading cause of pediatric hospital admission in Africa, with significant in-hospital mortality. The underlying etiology is often infectious, but specific pathogens ...
  • Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score 
    George, Elizabeth C.; Walker, Sarah; Kiguli, Sarah; Olupot-Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Berkley, James A.; Mpoya, Ayub; Levin, Michael; Crawley, Jane; Gibb, Diana M.; Maitland, Kathryn; Babiker, Abdel G. (BMC, 2015)
    Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ...
  • Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial 
    Mpoya, Ayub; Olupot-Olupot, Peter; Kiguli, Sarah; Opoka, Robert O.; Engoru, Charles; Macpherson, Mallewa; Chimalizeni, Yami; Kennedy, Neil; Kyeyune, Dorothy; Wabwire, Benjamin; M’baya, Bridon; Bates, Imelda; Urban, Britta C,; van Hensbroek, Michael Boele; Heyderman, Robert; Thomason, Margaret J.; Uyoga, Sophie; Williams, Thomas N.; Gibb, Diana M.; George, Elizabeth C.; Walker, Sarah; Maitland, Kathryn (BMC, 2015)
    Background: In sub-Saharan Africa, where infectious diseases and nutritional deficiencies are common, severe anaemia is a common cause of paediatric hospital admission, yet the evidence to support current treatment rec ...
  • Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment 
    Nightingale, Helen; Walsh, Kevin J.; Olupot-Olupot, Peter; Engoru, Charles; Ssenyondo, Tonny; Nteziyaremye, Julius; Amorut, Denis; Nakuya, Margaret; Arimi, Margaret; Frost, Gary; Maitland, Kathryn (BMC, 2016)
    Background: Undernutrition remains highly prevalent in African children, highlighting the need for accurately assessing dietary intake. In order to do so, the assessment method must be validated in the target population. ...
  • ‘The words will pass with the blowing wind’: staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two african hospitals 
    Molyneux, Sassy; Njue, Maureen; Boga, Mwanamvua; Akello, Lilian; Olupot-Olupot, Peter; Engoru, Charles; Kiguli, Sarah; Maitland, Kathryn (Public Library of Science, 2013)
    Objective: To document and explore the views and experiences of key stakeholders regarding the consent procedures of an emergency research clinical trial examining immediate fluid resuscitation strategies, and to discuss ...

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