Browsing Faculty of Health Sciences by Subject "African Children"

Browsing Faculty of Health Sciences by Subject "African Children"

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  • Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia 
    Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O.; Olupot-Olupot, Peter; Engoru, Charles; Njuguna, Patricia; Bandika, Victor; Mpoya, Ayub; Bush, Andrew; Williams, Thomas N.; Grieve, Richard; Sadique, Zia; Fraser, John; Harrison, David; Rowan, Kathy (Wellcome Trust, 2018)
    Background: In Africa, the clinical syndrome of pneumonia remains the leading cause of morbidity and mortality in children in the post-neonatal period. This represents a significant burden on in-patient services. The ...
  • Endotoxaemia is common in children with Plasmodium falciparum malaria 
    Olupot-Olupot, Peter; Urban, Britta C,; Jemutai, Julie; Nteziyaremye, Julius; Fanjo, Harry M.; Karanja, Henry; Karisa, Japhet; Ongodia, Paul; Bwonyo, Patrick; Gitau, Evelyn N.; Talbert, Alison; Akech, Samuel; Maitland, Kathryn (BMC, 2013)
    Background: Children presenting to hospital with recent or current Plasmodium falciparum malaria are at increased the risk of invasive bacterial disease, largely enteric gram-negative organisms (ENGO), which is associated ...
  • Mortality after fluid bolus in African children with severe infection 
    Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O.; CEngoru, Charles; Olupot-Olupot, Peter; Akech, Samuel; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Lang, Trudie; Brent, Bernadette; Evans, A. Evans; Tibenderana, James K.; Crawley, Jane; Russell, Elizabeth C.; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M. (Massachusetts Medical Society, 2011)
    Background The role of fluid resuscitation in the treatment of children with shock and lifethreatening infections who live in resource-limited settings is not established. Methods We randomly assigned children with ...
  • Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study) 
    Obonyo, Nchafatso; Brent, Bernadette; Olupot-Olupot, Peter; Kuipers, Irene; Wong, Sidney; Shiino, Kenji; Jonathan, Chan; Fraser, John; van Woense, Job B. M.; van Hensbroek, Michael Boele; Maitland, Kathryn (BMC, 2017)
    Background: Fluid therapy in severely malnourished children is hypothesized to be deleterious owing to compromised cardiac function. We evaluated World Health Organization (WHO) fluid resuscitation guidelines for hypovolaemic ...
  • Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia 
    Olupot-Olupot, Peter; Engoru, Charles; Thompson, Jennifer; Nteziyaremye, Julius; Chebet, Martin; Ssenyondo, Tonny; Dambisya, Cornelius M.; Okuuny, Vicent; Wokulira, Ronald; Amorut, Denis; Ongodia, Paul; Mpoya, Ayub; Williams, Thomas N.; Uyoga, Sophie; Macharia, Alex; Gibb, Diana M.; Walker, A. Sarah; Maitland, Kathryn (BMC, 2018)
    Background: Severe anemia (SA, hemoglobin <6 g/dl) is a leading cause of pediatric hospital admission in Africa, with significant in-hospital mortality. The underlying etiology is often infectious, but specific pathogens ...

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